Volume 9 Issue 6
Dec.  2023
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Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032
Citation: Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032

Regulation of cellular senescence by innate immunity

doi: 10.52601/bpr.2023.230032
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  • Corresponding author: zhengyiabc2011@sdu.edu.cn (Y. Zheng); cgao@sdu.edu.cn (C. Gao)
  • Received Date: 30 October 2023
  • Accepted Date: 12 January 2024
  • Available Online: 26 February 2024
  • Publish Date: 01 December 2023
  • During the COVID-19 pandemic, the interplay between the processes of immunity and senescence is drawing more and more intensive attention. SARS-CoV-2 infection induces senescence in lung cells, failure to clear infected cells and increased presence of inflammatory factors could lead to a cytokine storm and acute respiratory disease syndrome (ARDS), which together with aging and age-associated disease lead to 70% of COVID-19-related deaths. Studies on how senescence initiates upon viral infection and how to restrict excessive accumulation of senescent cells to avoid harmful inflammation are crucially important. Senescence can induce innate immune signaling, and innate immunity can engage cell senescence. Here, we mainly review the innate immune pathways, such as cGAS-STING, TLRs, NF-κB, and NLRP3 inflammasome, participating in the senescence process. In these pathways, IFN-I and inflammatory factors play key roles. At the end of the review, we propose the strategies by which we can improve the immune function and reduce inflammation based on these findings.

  • Jinxiu Hou, Yi Zheng, and Chengjiang Gao declare that they have no conflict of interest
    This article does not contain any studies with human or animal subjects performed by any of the authors.

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