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Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity. Biophysics Reports. doi: 10.52601/bpr.2023.230018
Citation: Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity. Biophysics Reports. doi: 10.52601/bpr.2023.230018

Oligomeric rearrangement may regulate channel activity

doi: 10.52601/bpr.2023.230018
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  • Corresponding author: yshen@nankai.edu.cn (Y. Shen)
  • Received Date: 11 October 2023
  • Accepted Date: 13 November 2023
  • Available Online: 26 February 2024
  • Channels are typically gated by several factors, including voltage, ligand and mechanical force. Most members of the calcium homeostasis modulator (CALHM) protein family, large-pore ATP release channels, exist in different oligomeric states. Dynamic conversions between CALHM1 heptamers and octamers to gate the channel were proposed. Meanwhile, the latest study observed that the transient receptor potential vanilloid 3 (TRPV3) channel adopts a dynamic transition between pentamers and canonical tetramers in response to small molecule treatment. These results suggest that oligomeric rearrangement may add a new layer to regulate the channel activities.

  • Yue Ren, Xue Yang and Yuequan Shen declare that they have no conflict of interest.
    This article does not contain any studies with human or animal subjects performed by any of the authors.

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