Turn off MathJax
Article Contents
Zong Jie Cui. The Golgi Ca2+ stores, and original contributions by Prof. Shao Bai Xue. Biophysics Reports. doi: 10.52601/bpr.2023.230015
Citation: Zong Jie Cui. The Golgi Ca2+ stores, and original contributions by Prof. Shao Bai Xue. Biophysics Reports. doi: 10.52601/bpr.2023.230015

The Golgi Ca2+ stores, and original contributions by Prof. Shao Bai Xue

doi: 10.52601/bpr.2023.230015
More Information
  • Corresponding author: zjcui@bnu.edu.cn (Z. J. Cui)
  • Received Date: 26 September 2023
  • Accepted Date: 06 November 2023
  • Available Online: 26 February 2024
  • The Golgi apparatus serves as a distinct part of intracellular Ca2+ stores. Here, the early discovery by Professor Shao Bai Xue is reviewed, and the recent progress in the field is outlined. Golgi Ca2+ stores-related functional proteins, such as secretory pathway Ca2+ ATPases (SPCA1/2) and the Golgi-specific Ca2+ releasing channel Golgi anti-apoptotic protein (GAAP), as well as the recently defined Golgi-specific Ca2+ release agent emetine, collectively corroborate the concept of the Golgi apparatus as unique internal Ca2+ stores.

  • Zong Jie Cui declares no conflict of interest.
    This article does not contain any studies with human or animal subjects performed by the author.

  • loading
  • Almeida N, Carrara G, Palmeira CM, Fernandes AS, Parsons M, Smith GL, Saraiva N (2020) Stimulation of cell invasion by the Golgi ion channel GAAP/TMBIM4 via an H2O2-dependent mechanism. Redox Biol 28: 101361. https://doi.org/10.1016/j.redox.2019.101361
    Aulestia FJ, Alonso MT, Garcia-Sancho J (2015) Differential calcium handling by the cis and trans regions of the Golgi apparatus. Biochem J 466: 455−465 doi: 10.1042/BJ20141358
    Carrara G, Parsons M, Saraiva N, Smith GL (2017) Golgi anti-apoptotic protein: a tale of camels, calcium, channels, and cancer. Open Biol 7: 170045. https://doi.org/10.1098/rsob.170045
    Carrara G, Saraiva N, Parsons M, Byrne B, Prole DL, Taylor CW, Smith GL (2015) Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration. J Biol Chem 290: 11785−11801 doi: 10.1074/jbc.M115.637306
    Chen JL, Sitsel A, Benoy V, Sepulveda MR, Vangheluwe P (2020) Primary active Ca2+ transport systems in health and disease. Cold Spring Harb Perspect Biol 12: a035113. https://doi.org/10.1101/cshperspect.a035113
    Chen ZH, Watanabe S, Hashida H, Inoue M, Daigaku Y, Kikkawa M, Inaba K (2023) Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into Golgi apparatus. Sci Adv 9: eadd9742. https://doi.org/10.1126/sciadv.add9742
    Cui J, Li Y, Xue SB (1995) Visualization of Golgi apparatus as an intracellular calcium store by laser scanning confocal microscope. Cell Res 5: 165−179 doi: 10.1038/cr.1995.16
    Cui ZJ (2019) Analytical cell biologist Professor Shao Bai Xue. Chin J Cell Biol 41: 2047−2056
    Cui ZJ (2023) The Golgi apparatus calcium stores. J Beijing Normal University (Natural Science) 59: 505−512
    Dolman NJ, Gerasimenko JV, Gerasimenko OV, Voronina SG, Petersen OH, Tepikin AV (2005) Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. J Biol Chem 280: 15794−15799 doi: 10.1074/jbc.M412694200
    Feng MY, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R (2010) Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell 143: 84−98 doi: 10.1016/j.cell.2010.08.040
    Gallegos-Gómez ML, Greotti E, López-Méndez MC, Sánchez-Vázquez VH, Arias JM, Guerrero-Hernández A (2018) The trans Golgi region is a labile intracellular Ca2+ store sensitive to Emetine. Sci Rep 8: 17143. https://doi.org/10.1038/s41598-018-35280-z
    Gilon P, Chae HY, Rutter GA, Ravier MA (2014) Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes. Cell Calcium 56: 340−361 doi: 10.1016/j.ceca.2014.09.001
    Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJ, Smith GL (2007) A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathog 3: e17. https://doi.org/10.1371/journal.ppat.0030017
    Hu ZL, Bonifas JM, Beech J, Bench G, Shigihara T, Ogawa H, Ikeda S, Mauro T, Ervin H. Epstein Jr EH (2000) Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat Genet 24: 61−65 doi: 10.1038/71701
    Klemens CA, Chulkov EG, Wu J, Khan MAH, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A (2021) Loss of chloride channel 6 (CLC-6) affects vascular smooth muscle contractility and arterial stiffness via alterations to Golgi calcium stores. Hypertension 77: 582−593 doi: 10.1161/HYPERTENSIONAHA.120.16589
    Konieczny V, Tovey SC, Mataragka S, Prole DL, Taylor CW (2017) Cyclic AMP recruits a discrete intracellular Ca2+ store by unmasking hypersensitive IP3 receptors. Cell Rep 18: 711−722 doi: 10.1016/j.celrep.2016.12.058
    Lan YJ, Cheng CC, Chu SC, Chiang YW (2023) A gating mechanism of the BsYetJ calcium channel revealed in an endoplasmic reticulum lipid environment. Biochim Biophys Acta Biomembr 1865: 184153. https://doi.org/10.1016/j.bbamem.2023.184153
    Li J, Wang Y (2022) Golgi metal ion homeostasis in human health and diseases. Cells 11: 289. https://doi.org/10.3390/cells11020289
    Li Y, Cui ZJ (2022) Photodynamic activation of cholecystokinin 1 receptor with different genetically encoded protein photosensitizers and from varied subcellular sites. Biomolecules 10: 1423. https://doi.org/10.3390/biom10101423
    Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG (1999) Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. J Cell Biol 145: 279−289 doi: 10.1083/jcb.145.2.279
    Miseta A, Fu LW, Bedwell DM (1999) The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33 Delta vacuolar biogenesis mutant of Saccharomyces cerevisiae. J Biol Chem 274: 5939−5947 doi: 10.1074/jbc.274.9.5939
    Pihán P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, Castillo K, Kepp O, Urra H, Saarnio S, Vihinen H, Carreras-Sureda A, Forveille S, Sauvat A, De Giorgis D, Pupo A, Rodríguez DA, Quarato G, Sagredo A, Lourido F, Letai A, Latorre R, Kroemer G, Demaurex N, Jokitalo E, Concha ML, Glavic Á, Green DR, Hetz C (2021) Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Sci Adv 7: eabe5469. https://doi.org/10.1126/sciadv.abe5469
    Pinton P, Pozzan T, Rizzuto R (1998) The Golgi apparatus is an inositol 1, 4, 5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J 17: 5298−5308 doi: 10.1093/emboj/17.18.5298
    Pizzo P, Lissandron V, Capitanio P, Pozzan T (2011) Ca2+ signalling in the Golgi apparatus. Cell Calcium 50: 184−192 doi: 10.1016/j.ceca.2011.01.006
    Pizzo P, Lissandron V, Pozzan T (2010) The trans-Golgi compartment: a new distinct intracellular Ca store. Commun Integr Biol 3: 462−464 doi: 10.4161/cib.3.5.12473
    Prins D, Michalak M (2011) Organellar calcium buffers. Cold Spring Harb Perspect Biol 3: a004069. https://doi.org/10.1101/cshperspect.a004069
    Smaardijk S, Chen JL, Kerselaers S, Voets T, Eggermont J, Vangheluwe P (2018) Store-independent coupling between the secretory pathway Ca2+ transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease. Biochim Biophys Acta - Mol Cell Res 1865: 855−862 doi: 10.1016/j.bbamcr.2018.03.007
    Smaardijk S, Chen J, Wuytack F, Vangheluwe P (2017) SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway. Tissue Cell 49: 141−149 doi: 10.1016/j.tice.2016.09.004
    Wang WA, Agellon LB, Michalak M (2019) Organellar calcium handling in the cellular reticular network. Cold Spring Harb Perspect Biol 11: a038265. https://doi.org/10.1101/cshperspect.a038265
    Wong AK, Capitanio P, Lissandron V, Bortolozzi M, Pozzan T, Pizzo P (2013) Heterogeneity of Ca2+ handling among and within Golgi compartments. J Mol Cell Biol 5: 266−276 doi: 10.1093/jmcb/mjt024
    Wu J, Prole DL, Shen Y, Lin Z, Gnanasekaran A, Liu Y, Chen L, Zhou H, Chen SR, Usachev YM, Taylor CW, Campbell RE (2014) Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum. Biochem J 464: 13−22 doi: 10.1042/BJ20140931
    Wu M, Wu C, Song T, Pan K, Wang Y, Liu Z (2023) Structure and transport mechanism of the human calcium pump SPCA1. Cell Res 33: 533−545 doi: 10.1038/s41422-023-00827-x
    Xue SB, Nicoud MR, Cui J, Jovin DJA (1994) High concentration of calciun ions in Golgi apparatus. Cell Res 4: 97−108 doi: 10.1038/cr.1994.10
    Yang ZK, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS (2015) The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway. Sci Signal 8: ra101. https://doi.org/10.1126/scisignal.aaa7677
    Zha XH, Chandra S, Ridsdale AJ, Morrison GH (1995) Golgi-apparatus is involved in intracellular Ca2+ regulation in epithelial cells LLC-PK1 cells. Am J Physiol Cell Physiol 268: C1133−C1140 doi: 10.1152/ajpcell.1995.268.5.C1133
    Zhang L, Buhr S, Voigt A, Methner A (2021) The evolutionary conserved transmembrane BAX inhibitor motif (TMBIM) containing protein family members 5 and 6 are essential for the development and survival of Drosophila melanogaster. Front Cell Dev Biol 9: 666484. https://doi.org/10.3389/fcell.2021.666484
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(1)

    Article Metrics

    Article views (158) PDF downloads(13) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return