Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler

Xuemei Zeng; Yihang Ruan; Lun Wang; Jinpeng Deng; Shuangqian Yan

doi:10.52601/bpr.2023.230003

Volume 9 Issue 3

Jun. 2023

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Xuemei Zeng, Yihang Ruan, Lun Wang, Jinpeng Deng, Shuangqian Yan. Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler[J]. Biophysics Reports, 2023, 9(3): 134-145. doi: 10.52601/bpr.2023.230003

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Xuemei Zeng, Yihang Ruan, Lun Wang, Jinpeng Deng, Shuangqian Yan. Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler[J]. Biophysics Reports, 2023, 9(3): 134-145. doi: 10.52601/bpr.2023.230003

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Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler

doi: 10.52601/bpr.2023.230003

1.
Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China
2.
The Straits Institute of Flexible Electronics (SIFE, Future Technologies), the Straits Laboratory of Flexible Electronics (SLoFE), Fujian Normal University, Fuzhou 350117, China

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Corresponding author: xmzeng@fjnu.edu.cn (X. Zeng); ifeshqyan@fjnu.edu.cn (S. Yan)
Received Date: 28 January 2023
Accepted Date: 16 March 2023

Available Online: 03 June 2023

Publish Date: 01 June 2023

Abstract

Abstract

Increased glycolysis for promoting adenosine triphosphate (ATP) generation is one of the hallmarks of cancer. Although reducing glucose intake or depriving cellular glucose can delay the growth of tumors to some extent, their therapeutic efficacy is a highly needed improvement for clinical translation. Herein, we found that mannose synergistic with glucose oxidase (GOx) can induce cell death by ATP inhibition, autophagy activation, and apoptosis protein upgradation. By using biodegradable zeolitic imidazolate frameworks (ZIF-8) as a nanocarrier (denoted as ZIF-8/M&G), the mannose and GOx can accumulate at the tumor site while having no obvious long-term toxicity. At the tumor site, GOx inhibits glycolysis by converting glucose and oxygen to H₂O₂ and gluconic acid, realizing oxidation therapy and expediting the degradation of the pH-responsive ZIF-8 nanoparticles, respectively. Simultaneously, mannose disturbs sugar metabolism and reduces oxygen consumption, which in turn promotes the GOx oxidation process. The concerted glycolysis inhibition through interactions between mannose and GOx endows ZIF-8/M&G nanospolier with excellent therapeutic efficacy both in vitro and in vivo. Synergistic glycolysis disturbance by the designed nanospoiler in this work proposes a versatile approach for metabolism disturbance to tumor treatment.
- Glycolysis disturbance,
- Energy deprivation,
- Drug delivery,
- Zeolitic imidazolate frameworks,
- Metal-organic frameworks

Xuemei Zeng, Yihang Ruan, Lun Wang, Jinpeng Deng and Shuangqian Yan declare that they have no Conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.

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