Antioxidant activity of the thioredoxin system

Zihua Liu

doi:10.52601/bpr.2023.230002

Volume 9 Issue 1

Feb. 2023

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Zihua Liu. Antioxidant activity of the thioredoxin system[J]. Biophysics Reports, 2023, 9(1): 26-32. doi: 10.52601/bpr.2023.230002

Citation:

Zihua Liu. Antioxidant activity of the thioredoxin system[J]. Biophysics Reports, 2023, 9(1): 26-32. doi: 10.52601/bpr.2023.230002

Zihua Liu. Antioxidant activity of the thioredoxin system[J]. Biophysics Reports, 2023, 9(1): 26-32. doi: 10.52601/bpr.2023.230002

Citation:

Zihua Liu. Antioxidant activity of the thioredoxin system[J]. Biophysics Reports, 2023, 9(1): 26-32. doi: 10.52601/bpr.2023.230002

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Antioxidant activity of the thioredoxin system

doi: 10.52601/bpr.2023.230002

Zihua Liu^,

1.
Department of blood transfusion school of second hospital, Lanzhou University, Lanzhou 730030, China

More Information

Corresponding author: liuwrax@126.com (Z. Liu)
Received Date: 12 January 2023
Accepted Date: 10 February 2023

Available Online: 11 May 2023

Publish Date: 28 February 2023

Abstract

Abstract

The thioredoxin system is composed of thioredoxin (Trx), thioredoxin reductase (TR) and reduced nicotinamide adenine dinucleotide phosphate. Trx is an important antioxidant molecule that can resist cell death caused by various stresses and plays a prominent role in redox reactions. TR is a protein that contains selenium (selenocysteine), in three main forms, namely, TR1, TR2 and TR3. TR1, TR2 and TR3 are mainly distributed in the cytoplasm, mitochondria, and testes, respectively. TR can regulate cell growth and apoptosis. After a cell becomes cancerous, the expression of TR is increased to promote cell growth and metastasis. The Trx system is closely related to neurodegenerative diseases, parasitic infections, acquired immunodeficiency syndrome, rheumatoid arthritis, hypertension, myocarditis, and so on. In addition, the Trx system can remove the reactive oxygen species in the body and keep the inside and outside of the cell in a balanced state. In summary, the Trx system is an important target for the drug treatment of many diseases.
- Thioredoxin,
- Thioredoxin reductase,
- Cancer,
- Neurodegenerative disease

Zihua Liu declares that he has no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.

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References(61)

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