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Yu Haonan, Liu Zhihua. GNA12 regulates C5a-induced migration by downregulating C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230001
Citation: Yu Haonan, Liu Zhihua. GNA12 regulates C5a-induced migration by downregulating C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230001

GNA12 regulates C5a-induced migration by downregulating C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling

doi: 10.52601/bpr.2023.230001
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  • Corresponding author: zhihualiu@mail.tsinghua.edu.cn (Z. Liu)
  • Received Date: 12 January 2023
  • Accepted Date: 21 February 2023
  • Available Online: 06 May 2023
  • Gna12 has been identified as one of the reported inflammatory bowel disease (IBD) susceptibility genes in genome-wide association studies (GWAS). However, the function of GNA12 in intestinal homeostasis remains unknown. Here we report that GNA12, a G-protein α subunit, regulates C5a-induced migration in macrophages. Deficiency of GNA12 results in enhanced migration induced by C5a in macrophages. Mechanistically, GNA12 suppresses C5a-induced migration by downregulating the C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling. Therefore, our study reveals that GNA12 is an anti-inflammatory factor, which might alleviate the development of inflammation by inhibiting the excessive chemotactic migration of macrophages.

  • Haonan Yu and Zhihua Liu declare that they have no conflict of interest.
    All institutional and national guidelines for the care and use of laboratory animals were followed.

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