Potential of adipose derived stem cell preparations in neurological repair and regeneration

Laura Combes; Xenia Sawkulycz; Wen-Hui Fang; Baoqiang Guo; Mark Slevin

doi:10.52601/bpr.2021.200025

Volume 7 Issue 2

Feb. 2021

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Laura Combes, Xenia Sawkulycz, Wen-Hui Fang, Baoqiang Guo, Mark Slevin. Potential of adipose derived stem cell preparations in neurological repair and regeneration[J]. Biophysics Reports, 2021, 7(2): 81-90. doi: 10.52601/bpr.2021.200025

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Laura Combes, Xenia Sawkulycz, Wen-Hui Fang, Baoqiang Guo, Mark Slevin. Potential of adipose derived stem cell preparations in neurological repair and regeneration[J]. Biophysics Reports, 2021, 7(2): 81-90. doi: 10.52601/bpr.2021.200025

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Potential of adipose derived stem cell preparations in neurological repair and regeneration

doi: 10.52601/bpr.2021.200025

1.
Department of Life Sciences, Manchester Metropolitan University, Manchester, UK
2.
Department of Biological and Geographical Sciences University of Huddersfield, Huddersfield, UK

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Corresponding author: l.combes@mmu.ac.uk (L. Combes); x.sawkulycz@mmu.ac.uk (X. Sawkulycz); m.a.slevin@mmu.ac.uk (M. Slevin)
Received Date: 09 July 2020
Accepted Date: 06 February 2021

Available Online: 17 May 2021

Publish Date: 28 February 2021

Abstract

Abstract

Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases. Decades of preclinical research has demonstrated stem cell ability to differentiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodulatory and immunosuppressive properties. This work has provided the fundamental scientific knowledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders, stroke, and other tissue injury. Despite the early success many of these promising therapies are yet to breakthrough into clinical use. In this review, we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved.
- Adipose derived mesenchymal stem cells,
- Micro-fragmented adipose tissue,
- Suicide gene therapy

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References(45)

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