2023 Vol. 9, No. 6

Cover Story

During the COVID-19 pandemic, the interplay between the processes of immunity and senescence is drawing more and more intensive attention. SARS-CoV-2 infection induces senescence in lung cells, failure to clear  infed sence of inflammatory factors could lead to a cytokine storm and acute respiratory disease syndrome (ARDS), which  together waing and age-associated disease lead to 70% of COVID-19- related deaths. Studies on how senescence initiates upon viral infection and how to restrict excessive accumulation of senescent cells to avoid harmful inflammation are crucially important. Senescence can induce innate immune signaling, and innate immunity can engage cell senescence. Here, the au-thors mainly review the innate immune pathways, such as cGAS-STING, TLRs, NF-κB, and NLRP3 inflammasome, participating in the senescence process. In these pathways, IFN-I and inflammatory factors play key roles. At the end of the review, the authors propose the strategies by which we can improve the immune function and reduce inflammation based on these findings.

Rapid quantification of 50 fatty acids in small amounts of biological samples for population molecular phenotyping
Establishment of a Fah-LSL mouse model to study BEC-to-hepatocyte conversion
Nucleoside deaminases: the key players in base editing toolkit
Regulation of cellular senescence by innate immunity
An artificial intelligence model for embryo selection in preimplantation DNA methylation screening in assisted reproductive technology