Regulation of cellular senescence by innate immunity

Jinxiu Hou; Yi Zheng; Chengjiang Gao

doi:10.52601/bpr.2023.230032

Volume 9 Issue 6

Dec. 2023

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Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity[J]. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032

Citation:

Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity[J]. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032

Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity[J]. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032

Citation:

Jinxiu Hou, Yi Zheng, Chengjiang Gao. Regulation of cellular senescence by innate immunity[J]. Biophysics Reports, 2023, 9(6): 338-351. doi: 10.52601/bpr.2023.230032

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Regulation of cellular senescence by innate immunity

doi: 10.52601/bpr.2023.230032

Jinxiu Hou^{1, 2},
Yi Zheng^{1, 2
,
,},
Chengjiang Gao^{1, 2
,
,}

1.
Key Laboratory of Infection and Immunity, Shandong Province & Key Laboratory for Experimental Teratology, Ministry of Education, Shandong University, Jinan 250012, China
2.
Department of Immunology, the School of Basic Medical Sciences, Shandong University, Jinan 250012, China

More Information

Corresponding author: zhengyiabc2011@sdu.edu.cn (Y. Zheng); cgao@sdu.edu.cn (C. Gao)
Received Date: 30 October 2023
Accepted Date: 12 January 2024

Available Online: 26 February 2024

Publish Date: 31 December 2023

Abstract

Abstract

During the COVID-19 pandemic, the interplay between the processes of immunity and senescence is drawing more and more intensive attention. SARS-CoV-2 infection induces senescence in lung cells, failure to clear infected cells and increased presence of inflammatory factors could lead to a cytokine storm and acute respiratory disease syndrome (ARDS), which together with aging and age-associated disease lead to 70% of COVID-19-related deaths. Studies on how senescence initiates upon viral infection and how to restrict excessive accumulation of senescent cells to avoid harmful inflammation are crucially important. Senescence can induce innate immune signaling, and innate immunity can engage cell senescence. Here, we mainly review the innate immune pathways, such as cGAS-STING, TLRs, NF-κB, and NLRP3 inflammasome, participating in the senescence process. In these pathways, IFN-I and inflammatory factors play key roles. At the end of the review, we propose the strategies by which we can improve the immune function and reduce inflammation based on these findings.
- IFN-I,
- NF-κB,
- cGAS-STING,
- TLRs,
- NLRP3 inflammasome,
- Cell senescence

Jinxiu Hou, Yi Zheng, and Chengjiang Gao declare that they have no conflict of interest
This article does not contain any studies with human or animal subjects performed by any of the authors.

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References(162)

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