Adaptive optics in super-resolution microscopy

Jingyu Wang; Yongdeng Zhang

doi:10.52601/bpr.2021.210015

Volume 7 Issue 4

Sep. 2021

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Jingyu Wang, Yongdeng Zhang. Adaptive optics in super-resolution microscopy[J]. Biophysics Reports, 2021, 7(4): 267-279. doi: 10.52601/bpr.2021.210015

Citation:

Jingyu Wang, Yongdeng Zhang. Adaptive optics in super-resolution microscopy[J]. Biophysics Reports, 2021, 7(4): 267-279. doi: 10.52601/bpr.2021.210015

Jingyu Wang, Yongdeng Zhang. Adaptive optics in super-resolution microscopy[J]. Biophysics Reports, 2021, 7(4): 267-279. doi: 10.52601/bpr.2021.210015

Citation:

Jingyu Wang, Yongdeng Zhang. Adaptive optics in super-resolution microscopy[J]. Biophysics Reports, 2021, 7(4): 267-279. doi: 10.52601/bpr.2021.210015

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Adaptive optics in super-resolution microscopy

doi: 10.52601/bpr.2021.210015

Jingyu Wang¹,
Yongdeng Zhang^{2, 3
,
,}

1.
Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, UK
2.
School of Life Sciences, Westlake University, Hangzhou 310024, China
3.
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China

Funds: J. Wang is supported by John Fell Fund award (141/144), Wellcome Trust awards (105605/Z/14/Z and 107457/Z/15/Z). Y. Zhang is supported by Westlake Education Foundation.

More Information

Corresponding author: zhangyongdeng@westlake.edu.cn (Y. Zhang)
Received Date: 01 June 2021
Accepted Date: 23 June 2021
Publish Date: 17 September 2021

Abstract

Abstract

Fluorescence microscopy has become a routine tool in biology for interrogating life activities with minimal perturbation. While the resolution of fluorescence microscopy is in theory governed only by the diffraction of light, the resolution obtainable in practice is also constrained by the presence of optical aberrations. The past two decades have witnessed the advent of super-resolution microscopy that overcomes the diffraction barrier, enabling numerous biological investigations at the nanoscale. Adaptive optics, a technique borrowed from astronomical imaging, has been applied to correct for optical aberrations in essentially every microscopy modality, especially in super-resolution microscopy in the last decade, to restore optimal image quality and resolution. In this review, we briefly introduce the fundamental concepts of adaptive optics and the operating principles of the major super-resolution imaging techniques. We highlight some recent implementations and advances in adaptive optics for active and dynamic aberration correction in super-resolution microscopy.
- Adaptive optics,
- Optical aberrations,
- Aberration correction,
- Wavefront sensor,
- Deformable mirror,
- Super-resolution microscopy

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References(81)

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