Volume 7 Issue 4
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Di Wu, Yinlian Zhang, Suwei Dong, Chao Zhong. Mutual interaction of microbiota and host immunity during health and diseases[J]. Biophysics Reports, 2021, 7(4): 326-340. doi: 10.52601/bpr.2021.200045
Citation: Di Wu, Yinlian Zhang, Suwei Dong, Chao Zhong. Mutual interaction of microbiota and host immunity during health and diseases[J]. Biophysics Reports, 2021, 7(4): 326-340. doi: 10.52601/bpr.2021.200045
shu

Mutual interaction of microbiota and host immunity during health and diseases

doi: 10.52601/bpr.2021.200045
  • 1.

    Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China

  • 2.

    State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Funds:  C. Zhong is supported by the National Natural Science Foundation of China (31770957 and 91842102) and the Natural Science Foundation of Beijing (18G10645).
More Information
  • Corresponding author: zhongc@pku.edu.cn (C. Zhong)
  • Received Date: 09 September 2020
  • Accepted Date: 17 June 2021
  • Publish Date: 17 September 2021
    Abstract
  • Microbiota–host interaction has attracted more and more attentions in recent years. The association between microbiota and host health is largely attributed to its influence on host immune system. Microbial-derived antigens and metabolites play a critical role in shaping the host immune system, including regulating its development, activation, and function. However, during various diseases the microbiota–host communication is frequently found to be disordered. In particular, gut microbiota dysbiosis associated with or led to the occurrence and progression of infectious diseases, autoimmune diseases, metabolic diseases, and neurological diseases. Pathogenic microbes and their metabolites disturb the protective function of immune system, and lead to disordered immune responses that usually correlate with disease exacerbation. In the other hand, the immune system also regulates microbiota composition to keep host homeostasis. Here, we will discuss the current advances of our knowledge about the interactions between microbiota and host immune system during health and diseases.
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