Latest developments on the mechanism of action of membrane disrupting peptides

Sara Pandidan; Adam Mechler

doi:10.52601/bpr.2021.200037

Volume 7 Issue 3

Jun. 2021

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Sara Pandidan, Adam Mechler. Latest developments on the mechanism of action of membrane disrupting peptides[J]. Biophysics Reports, 2021, 7(3): 173-184. doi: 10.52601/bpr.2021.200037

Citation:

Sara Pandidan, Adam Mechler. Latest developments on the mechanism of action of membrane disrupting peptides[J]. Biophysics Reports, 2021, 7(3): 173-184. doi: 10.52601/bpr.2021.200037

Sara Pandidan, Adam Mechler. Latest developments on the mechanism of action of membrane disrupting peptides[J]. Biophysics Reports, 2021, 7(3): 173-184. doi: 10.52601/bpr.2021.200037

Citation:

Sara Pandidan, Adam Mechler. Latest developments on the mechanism of action of membrane disrupting peptides[J]. Biophysics Reports, 2021, 7(3): 173-184. doi: 10.52601/bpr.2021.200037

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Latest developments on the mechanism of action of membrane disrupting peptides

doi: 10.52601/bpr.2021.200037

Sara Pandidan¹,
Adam Mechler^{1
,
,}

1.
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

More Information

Corresponding author: A.Mechler@latrobe.edu.au (A.Mechler)
Received Date: 01 August 2020
Accepted Date: 19 March 2021

Available Online: 07 July 2021

Publish Date: 30 June 2021

Abstract

Abstract

Antimicrobial peptides (AMPs) are integral components of the innate immune defence system of all complex organisms including plants, insects, and mammals. They have wide range of antibacterial, antifungal, antiviral, and even anticancer activities, therefore AMPs are attractive candidates for developing novel therapeutic approaches. Cationic α-helical membrane disrupting peptides are perhaps the most widely studied subclass of AMPs due to their common fundamental characteristics that allow for detailed structure-function analysis and therefore offer a promising solution to the threat of multidrug resistant strains of bacteria. The majority of the studies of AMP activity focused on the biological and biophysical aspects of membrane disruption; the understanding of the molecular mechanism of action from the physicochemical point of view forms a relatively small subfield. This review will provide an overview of these works, focusing on the empirical and thermodynamic models of AMP action.
- Antimicrobial peptides (AMPs),
- Membrane disrupting peptides,
- Empirical models,
- Thermodynamic models

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References(127)

References

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