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Jing Gao, Yuncong Chen, Zijian Guo, Weijiang He. Recent endeavors on molecular imaging for mapping metals in biology[J]. Biophysics Reports, 2020, 6(5): 159-178. doi: 10.1007/s41048-020-00118-7
Citation: Jing Gao, Yuncong Chen, Zijian Guo, Weijiang He. Recent endeavors on molecular imaging for mapping metals in biology[J]. Biophysics Reports, 2020, 6(5): 159-178. doi: 10.1007/s41048-020-00118-7
shu

Recent endeavors on molecular imaging for mapping metals in biology

doi: 10.1007/s41048-020-00118-7
  • 1.

    State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China


  • 2. Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China

Funds:  Yuncong Chen, Weijiang He
  • Received Date: 02 June 2020
  • Publish Date: 10 March 2021
    Abstract
  • Transition metals such as zinc, copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems. Molecular imaging including two-photon imaging (TPI), bioluminescence imaging (BLI) and photoacoustic imaging (PAI), could act as non-invasive toolkits for capturing dynamic events in living cells, tissues and whole animals. Herein, we review the recent progress in the development of molecular probes for essential transition metals and their biological applications. We emphasize the contributions of metallostasis to health and disease, and discuss the future research directions about how to harness the great potential of metal sensors.
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