“At last in” the physiological roles of the tubular ER network

Li Lü; Liling Niu; Junjie Hu

doi:10.1007/s41048-020-00113-y

Volume 6 Issue 4

Mar. 2021

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Li Lü, Liling Niu, Junjie Hu. “At last in” the physiological roles of the tubular ER network. Biophysics Reports, 2020, 6(4): 105-114. doi: 10.1007/s41048-020-00113-y

Citation:

Li Lü, Liling Niu, Junjie Hu. “At last in” the physiological roles of the tubular ER network. Biophysics Reports, 2020, 6(4): 105-114. doi: 10.1007/s41048-020-00113-y

Li Lü, Liling Niu, Junjie Hu. “At last in” the physiological roles of the tubular ER network. Biophysics Reports, 2020, 6(4): 105-114. doi: 10.1007/s41048-020-00113-y

Citation:

Li Lü, Liling Niu, Junjie Hu. “At last in” the physiological roles of the tubular ER network. Biophysics Reports, 2020, 6(4): 105-114. doi: 10.1007/s41048-020-00113-y

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“At last in” the physiological roles of the tubular ER network

doi: 10.1007/s41048-020-00113-y

1 Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China
2 Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute&Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China
3 National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Funds: Liling Niu, Junjie Hu

Received Date: 12 June 2020
Rev Recd Date: 01 July 2020
Publish Date: 31 August 2020

Abstract

Abstract

In eukaryotic cells, the endoplasmic reticulum (ER) forms a continuous network of tubules and sheets. ER membranes are inter-connected by a class of dynamin-like GTPases termed atlastins (ATLs). Deletion or mutation of ATLs results in long and unbranched ER tubules in cells. Mutations in ATL1 in humans have been linked to the neurodegenerative disease hereditary spastic paraplegia. The basis of ATL-mediated membrane fusion has been studied extensively, but specific functions of ATL remain unclear. In this review, we summarize ER-related cellular processes that directly or indirectly involve ATL, including membrane trafficking, lipid metabolism, autophagy, microtubule dynamics, pathogen infections, calcium signaling, and protein homeostasis. These findings provide important clues for deciphering the physiological roles of the tubular ER network.
- Atlastin,
- Membrane trafficking,
- Lipid metabolism,
- Autophagy,
- Microtubule dynamics,
- Pathogen infections,
- Calcium signaling,
- Protein homeostasis

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References(118)

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