Type II toxin-antitoxin system in bacteria: activation, function, and mode of action

Si-Ping Zhang; Qian Wang; Shuo-Wei Quan; Xiao-Quan Yu; Yong Wang; Ding-Ding Guo; Liang Peng; Hu-Yuan Feng; Yong-Xing He

doi:10.1007/s41048-020-00109-8

Volume 6 Issue 2-3

Feb. 2020

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Si-Ping Zhang, Qian Wang, Shuo-Wei Quan, Xiao-Quan Yu, Yong Wang, Ding-Ding Guo, Liang Peng, Hu-Yuan Feng, Yong-Xing He. Type II toxin-antitoxin system in bacteria: activation, function, and mode of action. Biophysics Reports, 2020, 6(2-3): 68-79. doi: 10.1007/s41048-020-00109-8

Citation:

Si-Ping Zhang, Qian Wang, Shuo-Wei Quan, Xiao-Quan Yu, Yong Wang, Ding-Ding Guo, Liang Peng, Hu-Yuan Feng, Yong-Xing He. Type II toxin-antitoxin system in bacteria: activation, function, and mode of action. Biophysics Reports, 2020, 6(2-3): 68-79. doi: 10.1007/s41048-020-00109-8

Citation:

Si-Ping Zhang, Qian Wang, Shuo-Wei Quan, Xiao-Quan Yu, Yong Wang, Ding-Ding Guo, Liang Peng, Hu-Yuan Feng, Yong-Xing He. Type II toxin-antitoxin system in bacteria: activation, function, and mode of action. Biophysics Reports, 2020, 6(2-3): 68-79. doi: 10.1007/s41048-020-00109-8

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Type II toxin-antitoxin system in bacteria: activation, function, and mode of action

doi: 10.1007/s41048-020-00109-8

1 Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
2 School of Pharmacy, Lanzhou University, Lanzhou 730000, China

Funds: Hu-Yuan Feng, Yong-Xing He

Received Date: 10 May 2019
Rev Recd Date: 20 January 2020
Publish Date: 13 February 2020

Abstract

Abstract

The toxin-antitoxin (TA) system is composed of a stable toxin and an unstable antitoxin that neutralizes the toxin. Being perhaps the most studied among the different TA types, type II TA systems are widely distributed and often exist in multiple copies within chromosomes of eubacteria and archaea. Exhibiting diverse molecular activities such as RNases, kinases, and acetyltransferases, type II TA systems have been confirmed to be involved in diverse biological processes including plasmid maintenance, phage inhibition, persistence, stress response, and biofilm formation. In this review, we summarize the current state of the research in the type II TA field, emphasizing the activation mechanism, structure-function relationship, and biological functions of type II TA systems.
- Toxin,
- Antitoxin,
- Persister,
- Horizontal gene transfer

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References(94)

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