AIM interneurons mediate feeding suppression through the TYRA-2 receptor in <em>C. elegans</em>

Jiajun Fu; Haining Zhang; Wenming Huang; Xinyu Zhu; Yi Sheng; Eli Song; Tao Xu

doi:10.1007/s41048-018-0046-2

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Jiajun Fu, Haining Zhang, Wenming Huang, Xinyu Zhu, Yi Sheng, Eli Song, Tao Xu. AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans. Biophysics Reports, 2018, 4(1): 17-24. doi: 10.1007/s41048-018-0046-2

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Jiajun Fu, Haining Zhang, Wenming Huang, Xinyu Zhu, Yi Sheng, Eli Song, Tao Xu. AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans. Biophysics Reports, 2018, 4(1): 17-24. doi: 10.1007/s41048-018-0046-2

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AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans

doi: 10.1007/s41048-018-0046-2

Jiajun Fu^1,2,
Haining Zhang^1,3,
Wenming Huang^1,3,
Xinyu Zhu^1,3,
Yi Sheng^1,3,
Eli Song^{1
,
,},
Tao Xu^{1,2,3
,}

1 National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2 College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
3 Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

Funds: This work was supported by grants from the Ministry of Science and Technology of the People's Republic of China (2016YFA0500203), the National Science Foundation of China (31770900, 31730054, 31270884), the Beijing Natural Science Foundation (5122026, 5092017), and the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2011087).

More Information

Corresponding author: Eli Song,songali@ibp.ac.cn;Tao Xu,xutao@ibp.ac.cn
Received Date: 12 May 2017
Rev Recd Date: 23 May 2017
Publish Date: 28 February 2018

Abstract

Abstract

Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gai/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.
- C. elegans,
- TYRA-2 receptor,
- AIM interneurons,
- Peripheral feeding regulation,
- Tyramine

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References(33)

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