Class C G protein-coupled receptors:reviving old couples with new partners

Thor C. Møller; David Moreno-Delgado; Jean-Philippe Pin; Julie Kniazeff

doi:10.1007/s41048-017-0036-9

Volume 3 Issue 4-6

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Thor C. Møller, David Moreno-Delgado, Jean-Philippe Pin, Julie Kniazeff. Class C G protein-coupled receptors:reviving old couples with new partners. Biophysics Reports, 2017, 3(4-6): 57-63. doi: 10.1007/s41048-017-0036-9

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Thor C. Møller, David Moreno-Delgado, Jean-Philippe Pin, Julie Kniazeff. Class C G protein-coupled receptors:reviving old couples with new partners. Biophysics Reports, 2017, 3(4-6): 57-63. doi: 10.1007/s41048-017-0036-9

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Class C G protein-coupled receptors:reviving old couples with new partners

doi: 10.1007/s41048-017-0036-9

Institut de Génomique Fonctionnelle(IGF), CNRS, INSERM, Univ. Montpellier, 34094 Montpellier, France

Funds: This work was supported by the CNRS, INSERM and Univ Montpellier, and by grants from the Agence National de la Recherche (ANR-12-BSV2-0015; ANR-13-RPIB-0009), the Fondation Recherche Médicale (FRM DEQ 20130326522). TCM was supported by a funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 627227.

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Corresponding author: Jean-Philippe Pin
Received Date: 24 October 2016
Rev Recd Date: 11 January 2017
Publish Date: 30 November 2017

Abstract

Abstract

G protein-coupled receptors (GPCRs) are key players in cell communication and are encoded by the largest family in our genome. As such, GPCRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPCRs:the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPCRs, the class F includes the frizzled receptors, and the class C includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. Class C receptors are far more complex than other GPCRs, being mandatory dimers, with each subunit being composed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class C GPCRs, and how this brings information for many other GPCRs.
- G protein-coupled receptors,
- Dimerization,
- Activation mechanism,
- Glutamate,
- GABA

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References(52)

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