Oligomeric rearrangement may regulate channel activity

Yue Ren; Xue Yang; Yuequan Shen

doi:10.52601/bpr.2023.230018

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Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230018

Citation:

Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230018

Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230018

Citation:

Yue Ren, Xue Yang, Yuequan Shen. Oligomeric rearrangement may regulate channel activity[J]. Biophysics Reports. doi: 10.52601/bpr.2023.230018

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Oligomeric rearrangement may regulate channel activity

doi: 10.52601/bpr.2023.230018

Yue Ren¹,
Xue Yang¹,
Yuequan Shen^{1
,
,}

1.
State Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China

More Information

Corresponding author: yshen@nankai.edu.cn (Y. Shen)
Received Date: 11 October 2023
Accepted Date: 13 November 2023

Available Online: 26 February 2024

Abstract

Abstract

Channels are typically gated by several factors, including voltage, ligand and mechanical force. Most members of the calcium homeostasis modulator (CALHM) protein family, large-pore ATP release channels, exist in different oligomeric states. Dynamic conversions between CALHM1 heptamers and octamers to gate the channel were proposed. Meanwhile, the latest study observed that the transient receptor potential vanilloid 3 (TRPV3) channel adopts a dynamic transition between pentamers and canonical tetramers in response to small molecule treatment. These results suggest that oligomeric rearrangement may add a new layer to regulate the channel activities.
- Channel,
- Gating,
- Oligomeric rearrangement,
- CALHM,
- TRP channel

Yue Ren, Xue Yang and Yuequan Shen declare that they have no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.

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References(23)

References

Bhat EA, Sajjad N, Banawas S, Khan J (2021) Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies. Mol Cell Biochem 476(10): 3711−3718

Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, Li X, Li S, Chen P, Wang L, Yu Y, Yuan Z (2021) Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv 7(35): eabe3600. https://doi.org/10.1126/sciadv.abe3600

Choi W, Clemente N, Sun W, Du J, Lu W (2019) The structures and gating mechanism of human calcium homeostasis modulator 2. Nature 576(7785): 163−167

Danielli S, Ma Z, Pantazi E, Kumar A, Demarco B, Fischer FA, Paudel U, Weissenrieder J, Lee RJ, Joyce S, Foskett JK, Bezbradica JS (2023) The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse. EMBO J 42(7): e111450. https://doi.org/10.15252/embj.2022111450

Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P (2008) A polymorphism in CALHM1 influences Ca2 + homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 133(7): 1149−1161

Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R (2020) Cryo-EM structures and functional properties of CALHM channels of the human placenta. Elife 9: e55853. https://doi.org/10.7554/eLife.55853

Foskett JK (2020) Structures of CALHM channels revealed. Nat Struct Mol Biol 27(3): 227−228

Hucho F, Weise C (2001) Ligand-Gated Ion Channels. Angew Chem Int Ed Engl 40(17): 3100−3116

Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ (2020) Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms. Elife 9: e58660. https://doi.org/10.7554/eLife.58660

Kariev AM, Green ME (2012) Voltage gated ion channel function: gating, conduction, and the role of water and protons. Int J Mol Sci 13(2): 1680−1709

Kefauver JM, Ward AB, Patapoutian A (2020) Discoveries in structure and physiology of mechanically activated ion channels. Nature 587(7835): 567−576

Lansky S, Betancourt JM, Zhang J, Jiang Y, Kim ED, Paknejad N, Nimigean CM, Yuan P, Scheuring S (2023) A pentameric TRPV3 channel with a dilated pore. Nature 621(7977): 206−214

Lee SN, Cho HJ, Jeong H, Ryu B, Lee HJ, Kim M, Yoo J, Woo JS, Lee HH (2023) Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel. Nat Commun 14(1): 1347. https://doi.org/10.1038/s41467-023-37040-8

Ma J, Qi X, Yang C, Pan R, Wang S, Wu J, Huang L, Chen H, Cheng J, Wu R, Liao Y, Mao L, Wang FC, Wu Z, An JX, Wang Y, Zhang X, Zhang C, Yuan Z (2018) Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors. Mol Psychiatry 23(4): 883−891

Ren Y, Li Y, Wang Y, Wen T, Lu X, Chang S, Zhang X, Shen Y, Yang X (2022) Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. J Biol Chem 298(5): 101838. https://doi.org/10.1016/j.jbc.2022.101838

Ren Y, Wen T, Xi Z, Li S, Lu J, Zhang X, Yang X, Shen Y (2020) Cryo-EM structure of the calcium homeostasis modulator 1 channel. Sci Adv 6(29): eaba8161. https://doi.org/10.1126/sciadv.aba8161

Su W, Qiao X, Wang W, He S, Liang K, Hong X (2023) TRPV3: Structure, Diseases and Modulators. Molecules 28(2): 774. https://doi.org/10.3390/molecules28020774

Syrjanen JL, Epstein M, Gomez R, Furukawa H (2023) Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nat Commun 14(1): 3821. https://doi.org/10.1038/s41467-023-39388-3

Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H (2020) Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol 27(2): 150−159

Taruno A (2018) ATP Release Channels. Int J Mol Sci 19(3): 808. https://doi.org/10.3390/ijms19030808

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan MM, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK (2013) CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495(7440): 223−226

Tombola F, Pathak MM, Isacoff EY (2006) How does voltage open an ion channel? Annu Rev Cell Dev Biol 22: 23-52

Woolley GA, Lougheed T (2003) Modeling ion channel regulation. Curr Opin Chem Biol 7(6): 710−714

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