Citation: | Tongren Yang, Chanchan Yu, Changrong Wang, Chunhui Li, Mengjie Zhang, Xiaofan Luo, Yuhua Weng, Anjie Dong, Xiaoqiong Li, Yulin Deng, Yuanyu Huang. The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake[J]. Biophysics Reports, 2020, 6(6): 266-277. doi: 10.1007/s41048-020-00121-y |
Ahn CB, Lee JH, Han DG, Kang HW, Lee SH, Lee JI, Son KH, Lee JW (2019) Simulated microgravity with floating environment promotes migration of non-small cell lung cancers. Sci Rep 9(1):14553
|
Bauer J, Wehland M, Infanger M, Grimm D, Gombocz E (2018) Semantic analysis of posttranslational modification of proteins accumulated in thyroid cancer cells exposed to simulated microgravity. Int J Mol Sci 19(8):2257
|
Braddock M (2020) From target identification to drug development in space:using the microgravity assist. Curr Drug Discov Technol 17(1):45-56
|
Clement G, Pavy-Le Traon A (2004) Centrifugation as a countermeasure during actual and simulated microgravity:a review.Eur J Appl Physiol 92(3):235-248
|
Crawford-Young SJ (2006) Effects of microgravity on cell cytoskeleton and embryogenesis. Int J Dev Biol 50(2-3):183-191
|
de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J (2007) Interfering with disease:a progress report on siRNAbased therapeutics. Nat Rev Drug Discov 6(6):443-453
|
Diab A, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N'Guyen L, Isorce N, Cosset FL, Zoulim F, Andrisani O, Durantel D (2017) Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication. Hepatology 66(6):1750-1765
|
Du L, Wang C, Meng L, Cheng Q, Zhou J, Wang X, Zhao D, Zhang J, Deng L, Liang Z, Dong A, Cao H (2018) The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers. Biomaterials 176:84-93
|
Egorov AD (1996) Qualification of human body reactions to microgravity. Aviakosm Ekolog Med 30(4):14-20
|
El Dika I, Lim HY, Yong WP, Lin CC, Yoon JH, Modiano M, Freilich B, Choi HJ, Chao TY, Kelley RK, Brown J, Knox J, Ryoo BY, Yau T, Abou-Alfa GK (2019) An open-label, multicenter, Phase I, dose escalation study with Phase II expansion cohort to determine the safety, pharmacokinetics, and preliminary antitumor activity of intravenous TKM-080301 in subjects with advanced hepatocellular carcinoma. Oncologist 24(6):747-e218
|
Eyal S, Derendorf H (2019) Medications in space. In Search of a Pharmacologist's Guide to the Galaxy. Pharm Res 36(10):148. https://doi.org/10.1007/s11095-019-2679-3
|
Foca A, Dhillon A, Lahlali T, Lucifora J, Salvetti A, Rivoire M, Lee A, Durantel D (2020) Antiviral activity of PLK1-targeting siRNA delivered by lipid nanoparticles in HBV-infected hepatocytes. Antivir Ther. https://doi.org/10.3851/imp3361
|
Gonzalez-Aseguinolaza G (2020) Givosiran-running RNA interference to fight porphyria attacks. N Engl J Med 382(24):2366-2367
|
Grimm D, Bauer J, Kossmehl P, Shakibaei M, Schoberger J, Pickenhahn H, Schulze-Tanzil G, Vetter R, Eilles C, Paul M, Cogoli A (2002) Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB J 16(6):604-606
|
Hoy SM (2018) Patisiran:first global approval. Drugs 78(15):1625-1631
|
Hu B, Weng Y, Xia XH, Liang XJ, Huang Y (2019) Clinical advances of siRNA therapeutics. J Gene Med 21(7):e3097. https://doi.org/10.1002/jgm.3097
|
Hu B, Zhong L, Weng Y, Peng L, Huang Y, Zhao Y, Liang XJ (2020) Therapeutic siRNA:state of the art. Signal Transduct Target Ther 5(1):101. https://doi.org/10.1038/s41392-020-0207-x
|
Huang YY (2019) Approval of the first-ever RNAi therapeutics and its technological development history. Prog Biochem Biophys 46(3):313-322
|
Jhala DV, Kale RK, Singh RP (2014) Microgravity alters cancer growth and progression. Curr Cancer Drug Targets 14(4):394-406
|
Kong Y, Liu H, Li W, Wang D (2019) Intestine-specific activity of insulin signaling pathway in response to microgravity stress in Caenorhabditis elegans. Biochem Biophys Res Commun 517(2):278-284
|
Li J, Zhang S, Chen J, Du T, Wang Y, Wang Z (2009) Modeled microgravity causes changes in the cytoskeleton and focal adhesions, and decreases in migration in malignant human MCF-7 cells. Protoplasma 238(1-4):23-33
|
Li Y, Gao X, Ling S, Zhong G, Sun W, Liu C, Li J, Song J, Zhao D, Jin X, Li Y, Sun X-Q (2020) Knockdown of CD44 inhibits the alteration of osteoclast function induced by simulated microgravity. Acta Astronaut 166:607-612
|
Liu Z, Sun Q, Wang X (2017) PLK1, a potential target for cancer therapy. Transl Oncol 10(1):22-32
|
Loomer PM (2001) The impact of microgravity on bone metabolism in vitro and in vivo. Crit Rev Oral Biol Med 12(3):252-261
|
Masiello MG, Cucina A, Proietti S, Palombo A, Coluccia P, D'Anselmi F, Dinicola S, Pasqualato A, Morini V, Bizzarri M (2014) Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells. Biomed Res Int 2014:652434. https://doi.org/10.1155/2014/652434
|
Norsk P (2020) Adaptation of the cardiovascular system to weightlessness:surprises, paradoxes and implications for deep space missions. Acta Physiol (Oxf)228(3):e13434. https://doi.org/10.1111/apha.13434
|
Ohta H, Baba A, Gabriel K (2002) Review of existing research on microgravity boiling and two-phase flow:future experiments on the international space station. Ann N Y Acad Sci 974:410-427
|
Paulsen K, Tauber S, Dumrese C, Bradacs G, Simmet DM, Golz N, Hauschild S, Raig C, Engeli S, Gutewort A, Hurlimann E, Biskup J, Unverdorben F, Rieder G, Hofmanner D, Mutschler L, Krammer S, Buttron I, Philpot C, Huge A, Lier H, Barz I, Engelmann F, Layer LE, Thiel CS, Ullrich O (2015) Regulation of ICAM-1 in cells of the monocyte/macrophage system in microgravity. Biomed Res Int 2015:538786
|
Reichert P, Prosise W, Fischmann TO, Scapin G, Narasimhan C, Spinale A, Polniak R, Yang X, Walsh E, Patel D, Benjamin W, Welch J, Simmons D, Strickland C (2019) Pembrolizumab microgravity crystallization experimentation. NPJ Microgravity 5:28
|
Roberts DR, Asemani D, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, George MS, Brown TR (2019) Prolonged microgravity affects human brain structure and function. AJNR Am J Neuroradiol 40(11):1878-1885
|
Scott LJ (2020) Givosiran:first approval. Drugs 80(3):335-339
|
Shi W, Xie Y, He J, Zhou J, Gao Y, Wei W, Ding N, Ma H, Xian CJ, Chen K, Wang J (2017) Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia. Sci Rep 7(1):1866. https://doi.org/10.1038/s41598-017-02049-9
|
Shi W, Zhang Y, Chen K, He J, Feng X, Wei W, Hua J, Wang J (2020) Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization. Bone 136:115346. https://doi.org/10.1016/j.bone.2020.115346
|
Strube F, Infanger M, Wehland M, Delvinioti X, Romswinkel A, Dietz C, Kraus A (2020) Alteration of cytoskeleton morphology and gene expression in human breast cancer cells under simulated microgravity. Cell J 22(1):106-114
|
Uchida T, Sakashita Y, Kitahata K, Yamashita Y, Tomida C, Kimori Y, Komatsu A, Hirasaka K, Ohno A, Nakao R, Higashitani A, Higashibata A, Ishioka N, Shimazu T, Kobayashi T, Okumura Y, Choi I, Oarada M, Mills EM, Teshima-Kondo S, Takeda S, Tanaka E, Tanaka K, Sokabe M, Nikawa T (2018) Reactive oxygen species upregulate expression of muscle atrophyassociated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells. Am J Physiol Cell Physiol 314(6):C721-C731
|
Wang H, Sun Z, Wang Y, Hu Z, Zhou H, Zhang L, Hong B, Zhang S, Cao X (2016) miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2. Sci Rep 6:23170. https://doi.org/10.1038/srep23170
|
Weng Y, Xiao H, Zhang J, Liang XJ, Huang Y (2019) RNAi therapeutic and its innovative biotechnological evolution. Biotechnol Adv 37(5):801-825
|
Whitehead KA, Dorkin JR, Vegas AJ, Chang PH, Veiseh O, Matthews J, Fenton OS, Zhang Y, Olejnik KT, Yesilyurt V, Chen D, Barros S, Klebanov B, Novobrantseva T, Langer R, Anderson DG (2014) Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nat Commun 5:4277. https://doi.org/10.1038/ncomms5277
|
Wostyn P, Mader TH, Gibson CR, Killer HE (2019) The escape of retrobulbar cerebrospinal fluid in the astronaut's eye:mission impossible? Eye (Lond)33(10):1519-1524
|
Wu C, Wang W, Fang L, Su W (2018) Programmable pyrroleimidazole polyamides:a potent tool for DNA targeting. Chin Chem Lett 29(7):1105-1112
|
Zhang M, Weng Y, Cao Z, Guo S, Hu B, Lu M, Guo W, Yang T, Li C, Yang X, Huang Y (2020) ROS-Activatable siRNA-engineered polyplex for NIR-triggered synergistic cancer treatment. ACS Appl Mater Interfaces 12(29):32289-32300
|
Zhao D, Yang G, Liu Q, Liu W, Weng Y, Zhao Y, Qu F, Li L, Huang Y (2020) A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery. Nanoscale 12(20):10939-10943
|
Zhou J, Wu Y, Wang C, Cheng Q, Han S, Wang X, Zhang J, Deng L, Zhao D, Du L, Cao H, Liang Z, Huang Y, Dong A (2016) pHSensitive nanomicelles for high-efficiency siRNA delivery in vitro and in vivo:an insight into the design of polycations with robust cytosolic release. Nano Lett 16(11):6916-6923
|